Apitherapy as a possible complementary treatment for Parkinson’s disease

Authors

  • Wissem Hadjer Belabid Applied Genetic in Agriculture, Ecology and Public Health Laboratory, SNV/STU Faculty, of Abou Bekr Belkaid, Tlemcen 13000, Algeria
  • Semir Bechir Suheil Gaouar Applied Genetic in Agriculture, Ecology and Public Health Laboratory, SNV/STU Faculty, of Abou Bekr Belkaid, Tlemcen 13000, Algeria.
  • Houssam Boulenouar CancerLab Research Laboratory, Faculty of Medicine, Abou Bekr Belkaid Univerity of Tlemcen 13000, Algeria
  • Chahra Mostefaoui Applied Genetic in Agriculture, Ecology and Public Health Laboratory, SNV/STU Faculty, of Abou Bekr Belkaid, Tlemcen 13000, Algeria

Keywords:

Algeria, Neurodegenerative disease, Parkinson, Apitherapy

Abstract

Parkinson's disease (PD) is becoming increasingly prevalent in Algeria. Nonetheless, only few studies were carried on this very common neurodegenerative disease in the country, especially in the wilaya of Tlemcen. The medical treatment of PD only offers symptoms relief care and is usually expensive. That is part of the reason why great interest is given to Apitherapy treatments nowadays. Alternative medicine, especially Apitherapy is included in complementary and integrative medicine, which was the goal of our study. Part of our extended study on PD aimed to investigate the effect of Apitherapy, using propolis, bee pollen, honey, and royal jelly. 60 Parkinson patinas immersed in the ON phase of the disease added an Apitherapeutic treatment with their previous treatments. We noted that with the association of the Apitherapeutic treatment and the basic treatment, the motor signs have diminished. 78.3% of the cases have passed from the ON phase to the OFF phase. In addition, we confirm that the used Apitherapeutic treatment in association with the basic treatment proves to be very effective unlike when either of them is used alone.

References

A Nitecka-Buchta, P. Buchta, E. Tabenska-Bosakowska, K. Walczynska-Dragon, and S. Baron, “Myorelaxant effect of bee venom topical skin application in patients with RDC/TMD Ia and RDC/TMD Ib: a randomized, double blinded study,” BioMed Research International, vol. 2014, Article ID 296053, 9 pages, 2014

Alvarez-Fischer, D. ; Noelker, C.; Vulinovic, F.; Grunewald, A.; Chevarin, C.; Klein, C.; Oertel, Wh; Hirsch, Ec; Michel, Pp; Hartmann, A. (2013). Le venin d'abeille et son composant apamine en tant qu'agents neuroprotecteurs dans un modèle murin de la maladie

A.T. R. Goes, C. R. Jesse, M. S. Antunes. Fernando V.Lobo Ladd . AlinyA.B.Lobo Ladd. Cristianeluchese. CristianeLuchese. Nataliaparoul. SilvanaP.Boeira (2018.)“Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson’s disease: involvement of neuroinflammation and neurotrophins,” Chemico-Biological Interactions, vol. 279, pp. 111–120.e Parkinson. PLoS ONE, 8, e61700.

D. Alvarez-Fischer, C. Noelker, F. Vulinović et al., “Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model,” PLoS One, vol. 8, no. 4, p. e61700, 2013.

D.G. Healy, M. Falchi, S.S. O'sullivan, V. Bonifati, A. Durr, S. Bressman, A. Brice, J. Aasly, C.P. Zabetian, S. Goldwurm, J.J. Ferreira, E. Tolosa, D.M. Kay, C. Klein, D.R. Williams, C. Marras, A.E. Lang, Z.K. Wszolek, J. Berciano, A.H. Schapira, T. Lynch, K.P. Bhatia, T. Gasser, A.J. Lees, N.W. (2008). Wood, Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study, Lancet Neurol. Vol 7 (7) 583–590.

J. Kocot, M. Kiełczykowska, D. Luchowska-Kocot, J. Kurzepa, and I. Musik, “Antioxidant potential of propolis, bee pollen, and royal jelly: possible medical application,” Oxidative Medicine and Cellular Longevity, vol. 2018, 7074229 pages, 2018.

J. Kachergus, Iee.F. Mata, M. Hulihan, J.P. Taylor, S. Lincoln, J. Aasly, J.M. Gibson, O.A. Ross, T. Lynch, J. Wiley, H. Payami, J. Nutt, D.M. Maraganore, K. Czyzewski, M. Styczynska, Z.K. Wszolek, M.J. Farrer, M. Toft,(2005).Identification of a novel LRRK2 Mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations, Am. J. Hum. Genet. vol76 672–680

J.D. Lee, H.J. Park, Y. Chae, S. Lim An overview of beevenom acupuncture in the treatment of arthritis. evid.-basedcomplement Alternat. Med., 2 (2005), pp. 79-84

L. Cornara, M. Biagi, J. Xiao, and B. Burlando, “Therapeutic properties of bioactive compounds from different honeybee products,” Frontiers in Pharmacology, vol. 8, p. 412, 2017.

Lee, Jae-Dong; Park, Hi-Joon; Chae, Younbyoung; Lim, Sabina (2005). An Overview of Bee Venom Acupuncture in the Treatment of Arthritis. Evidence-BasedComplementary and Alternative Medicine, 2(1), 79–84. doi:10.1093/ecam/neh070

Lau L. M. and Breteler M. M. (2006) Epidemiology of Parkinson’s disease. Lancet Neurol 5, 525–535.

M. Taherianfard, S. AhmadiJokani Et Z. Khaksar. (2017) ."La gelée royale peut moduler les troubles comportementaux et histomorphométriques causés par la maladie de Parkinson chez le rat", Physiologie et pharmacologie. , vol. 21, non. 2, p. 120–128.

MassanonJoão ; Kailash P. Bhatia1 (2012) ClinicalApproach to Parkinson'sDisease: Features, Diagnosis, and Principles of Managemen

P. Perez-Pardo, T. Kliest, HbDodiya(2017). "L'axe intestin-cerveau dans la maladie de Parkinson : possibilités de thérapies basées sur l'alimentation", European Journal of Pharmacolog , vol. 817, p. 86–95,.

P.M. FratelloneApitherapyproducts for medicinaluseJ. Nutr. Food Sci., 5 (2015), p. 6

Semchuk KM, Love EJ, Lee RG. (1992).Parkinson’s disease and exposure to agricultural work and pesticide chemicals. Neurology;42: 1328-1335.

Sf Clarke, Ef Murphy, O. O'sullivan (2014). "L'exercice et les extrêmes alimentaires associés ont un impact sur la diversité microbienne intestinale", Gut , vol. 63, non. 12, p. 1913–1920.

T. Doko, I. Salaric, K. BazdarikComplementary and alternative medicine use amongCroatianhealthstudiesstudents - a single center cross-sectionalstudy Acta Med. Acad., 49 (2020), pp. 240-248

V.R. Pasupuleti, L. Sammugam, N. Ramesh, S.H. GanHoney, propolis, and royal jelly: acomprehensivereview of theirbiological actions and healthbenefitsOxida. Med. Cell. Longev., 2017 (2017), pp. 1-21

Y. Wang, J. Gao, Y. Miao. (2014)."La pinocembrine protège les cellules SH-SY5Y contre la neurotoxicité induite par le MPP+ par la voie apoptotique mitochondriale", Journal of Molecular Neuroscience , vol. 53, non. 4, p. 537–545.

Y. Al,Naggar, J.P. Giesy, M.M. Abdel-Daim, M.J. Ansari, S.N. Al-Kahtani, G. Yahya Fightingagainst the second wave of COVID-19: canhoneybeeproducts help protectagainst the pandemic? Saudi J. Biol. Sci., 28 (2021), pp. 1519-1527

Published

2024-11-09

How to Cite

Belabid, W. H., Gaouar, S. B. S., Boulenouar, H., & Mostefaoui, C. (2024). Apitherapy as a possible complementary treatment for Parkinson’s disease. International Journal of Economic Perspectives, 18(11), 2141–2152. Retrieved from http://ijeponline.org/index.php/journal/article/view/707

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Section

Peer Review Articles