Pharmacological study of Solanum nigrum fruit extract

Authors

  • Rudra Pratap Singh

Abstract

Popular demand and scientific interest in complementary or alternative medicine has increased considerably in recent year. The aim of present study to to evaluate the analgesic, anti-inflammatory and antimicrobial activities of ethanolic extract of fruits of Solanum nigrum plant belonging to Solanaceae family. The anti-inflammatory activity of the extract was evaluated by using Carrageenan-induced rat paw edema while analgesic activity of the extract was evaluated for its central and peripheral pharmacological actions by using Eddy's hot plate and acetic acid induced writhing respectively. The study was carried out using doses of 100, 200, 400 & 600 mg/kg orally. The extract showed significant analgesic and anti-inflammatory activity at the dose of 600 mg/kg (P<0.01) as compare to standard drug Diclofenac sodium (50 mg/kg). The plant extract significantly inhibited the S. aureus and B. sublitis (Gram +ve) at all the tested concentrations (100, 75, 50 and 25mg/ml) as compare to standard drug Ciprofloxacin (20 µg/ml) whereas the extract failed to show inhibitory effect against E. coli and P. aeruginosa (Gram –ve) at a concentration of 25mg/ml. The extract also showed significant inhibitory effect against C. albicans at all concentrations except at 25mg/ml as compare to standard drug Amphotericin B (100µg/ml).

Published

2021-10-31

How to Cite

Rudra Pratap Singh. (2021). Pharmacological study of Solanum nigrum fruit extract. International Journal of Economic Perspectives, 15(1), 564–575. Retrieved from http://ijeponline.org/index.php/journal/article/view/202

Issue

Vol. 15 No. 1 (2021)

Section

Peer Review Articles
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